Diltiazem Induces Severe Photodistributed Hyperpigmentation

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Diltiazem induces severe photodistributed hyperpigmentation: case series, histoimmunopathology, management, and review of the literature.

BACKGROUND Diltiazem hydrochloride is a commonly prescribed benzothiazepine calcium channel blocker for the treatment of cardiovascular disease. Recently, 8 cases of diltiazem-induced photodistributed hyperpigmentation occurring predominantly in elderly African American women were reported. Here, we report occurrence for the first time in a light-skinned African American woman and a Hispanic wo...

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Diltiazem-associated photodistributed hyperpigmentation: a review of 4 cases.

BACKGROUND Diltiazem hydrochloride is a widely used calcium channel blocking agent. While a few cases of diltiazem-associated photosensitivity have been reported, no cases of photodistributed hyperpigmentation are known. OBSERVATION Four cases of photodistributed hyperpigmentation associated with the long-acting formulation of diltiazem hydrochloride (Cardizem CD) are presented. All patients ...

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Severe dermatitis caused by diltiazem.

A.R. Rodríguez-Orozco , E.G. Kanán-Cedeño, C.E. Barbosa-Sánchez , R.G. Tejeda-Cárdenas , M.E. Vázquez-Romero , A. León-Gutiérrez c a División de Posgrado. Facultad de Medicina «Dr. Ignacio Chávez», Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mexico b Instituto de Investigación Científica en Temas de Familia, Alergia e Inmunología, Morelia, Mexico c Facultad de Psicología, Univers...

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Photodistributed erythema multiforme.

Although the existence of photodistributed erythema multiforme has been recognized for years, few cases have been described to date. It is an uncommon, and probably underdiagnosed, skin disorder that can affect individuals of both sexes and all ages. It has been associated with drugs, reactivation of herpes simplex virus infection, and polymorphous light eruption. A diagnosis is made on the bas...

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Severe Diltiazem Poisoning Treated with Hyperinsulinaemia-Euglycaemia and Lipid Emulsion

Introduction. Calcium channel blockers (CCBs) drugs are widely used in the treatment of cardiovascular diseases. CCB poisoning is associated with significant cardiovascular toxicity and is potentially fatal. Currently, there is no specific antidote and the treatment of CCB poisoning is supportive; however, this supportive therapy is often insufficient. We present a clinical case of severe dilti...

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ژورنال

عنوان ژورنال: Archives of Dermatology

سال: 2006

ISSN: 0003-987X

DOI: 10.1001/archderm.142.2.206